منابع مشابه
Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
PURPOSE Activation of polyol pathway due to increased aldose reductase (ALR2) activity has been implicated in the development of diabetic complications including diabetic retinopathy (DR), a leading cause of blindness. However, the relationship between hyperglycemia-induced activation of polyol pathway in retina and DR is still uncertain. We investigated the relationship between ALR2 levels and...
متن کاملIn vitro and in vivo reduction of erythrocyte sorbitol by ascorbic acid.
The in vitro accumulation of sorbitol by human erythrocytes incubated in a physiological glucose medium was found to be strongly reduced by the addition of ascorbic acid (AA). A maximal inhibition of sorbitol in the erythrocytes of 98.3% occurred when the concentration of AA was at its peak in the cells. After incubation, the erythrocyte sorbitol was found to be inversely correlated with the co...
متن کاملEffects of hyperglycaemia and sorbitol accumulation on erythrocyte deformability in diabetes mellitus.
Erythrocyte deformability was studied in a total of 83 poorly controlled diabetics (mean blood glucose 12.2 mmol/l) who were divided into three groups, each with matched healthy controls. There was no appreciable difference between diabetics and matched controls regarding the filtration of erythrocytes through 3 micron diameter straight channel pores (25 diabetics) or tortuous channel pores (28...
متن کاملErythrocyte aging and disease A tale of membranes and microparticles
Ned Tijdschr Klin Chem Labgeneesk 2016, vol. 41, no. 3 This chapter is an introduction to the research on erythrocytes, microparticles and regulatory T cells that is presented in the subsequent chapters. The first part of this chapter briefly discusses the main functions and characteristics of the erythrocyte. The second part focusses on erythrocyte aging and removal, transfusion side effects, ...
متن کاملErythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy.
The relationship between the effect of aldose reductase inhibitors (ARIs) on the activation of the polyol pathway and on diabetic neuropathy has not been fully established. To address this issue, we investigated the effect of epalrestat (150 mg/day), an ARI, on erythrocyte sorbitol levels as an index of polyol activation and on nerve function test results in 43 patients with diabetic peripheral...
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ژورنال
عنوان ژورنال: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
سال: 1987
ISSN: 0300-9173
DOI: 10.3143/geriatrics.24.476